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Papillary urothelial neoplasm of low malignant potential (PUN-LMP): Still a meaningful histo-pathological grade category for Ta, noninvasive bladder tumors in 2019?

Hentschel, Anouk E. ; van Rhijn, Bas W. G. ; Bründl, Johannes ; Compérat, Eva M. ; Plass, Karin ; Rodríguez, Oscar ; Henríquez, Jose D. Subiela ; Hernández, Virginia ; de la Peña, Enrique ; Alemany, Isabel ; Turturica, Diana ; Pisano, Francesca ; Soria, Francesco ; Čapoun, Otakar ; Bauerová, Lenka ; Pešl, Michael ; Bruins, H. Max ; Runneboom, Willemien ; Herdegen, Sonja ; Breyer, Johannes ; Brisuda, Antonin ; Scavarda-Lamberti, Andrea ; Calatrava, Ana ; Rubio-Briones, José ; Seles, Maximilian ; Mannweiler, Sebastian ; Bosschieter, Judith ; Kusuma, Venkata R. M. ; Ashabere, David ; Huebner, Nicolai ; Cotte, Juliette ; Mertens, Laura S. ; Cohen, Daniel ; Lunelli, Luca ; Cussenot, Olivier ; Sheikh, Soha El ; Volanis, Dimitrios ; Coté, Jean-François ; Rouprêt, Morgan ; Haitel, Andrea ; Shariat, Shahrokh F. ; Mostafid, A. Hugh ; Nieuwenhuijzen, Jakko A. ; Zigeuner, Richard ; Dominguez-Escrig, Jose L. ; Hacek, Jaromir ; Zlotta, Alexandre R. ; Burger, Maximilian ; Evert, Matthias ; Hulsbergen-van de Kaa, Christina A. ; van der Heijden, Antoine G. ; Kiemeney, Lambertus A. L. M. ; Soukup, Viktor ; Molinaro, Luca ; Gontero, Paolo ; Llorente, Carlos ; Algaba, Ferran ; Palou, Joan ; N'Dow, James ; Babjuk, Marko ; van der Kwast, Theo H. ; Sylvester, Richard J.



Abstract

Background: Papillary urothelial neoplasm of low malignant potential (PUN-LMP) was introduced as a noninvasive, noncancerous lesion and a separate grade category in 1998. Subsequently, PUN-LMP was reconfirmed by World Health Organization (WHO) 2004 and WHO 2016 classifications for urothelial bladder tumors. Objectives: To analyze the proportion of PUN-LMP diagnosis over time and to determine its ...

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