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Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Giladi, Amir ; Wagner, Lisa Katharina ; Li, Hanjie ; Dörr, Dorothea ; Medaglia, Chiara ; Paul, Franziska ; Shemer, Anat ; Jung, Steffen ; Yona, Simon ; Mack, Matthias ; Leutz, Achim ; Amit, Ido ; Mildner, Alexander


Mildner and colleagues characterize two subsets (Cxcl10(+) and Saa3(+)) of monocytes with pathogenic potential in the central nervous system of mice with experimentally induced autoimmune encephalomyelitis and show these pathogenic cells are not derived from Ly6C(+) monocytes, but from early myeloid cell progenitors. Multiple sclerosis (MS) is characterized by pathological inflammation that ...


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