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Combined radiotherapy and concurrent tumor treating fields (TTFields) for glioblastoma: Dosimetric consequences on non-coplanar IMRT as initial results from a phase I trial

Guberina, N. ; Pöttgen, C. ; Kebir, S. ; Lazaridis, L. ; Scharmberg, C. ; Lübcke, W. ; Niessen, M. ; Guberina, M. ; Scheffler, B. ; Jendrossek, V. ; Jabbarli, R. ; Pierscianek, D. ; Sure, U. ; Schmidt, T. ; Oster, C. ; Hau, P. ; Grosu, A. L. ; Stuschke, M. ; Glas, M. ; Nour, Y. ; Lüdemann, L.



Abstract

Background Glioblastoma is a rapidly proliferating tumor. Patients bear an inferior prognosis with a median survival time of 14-16 months. Proliferation and repopulation are a major resistance promoting factor for conventionally fractionated radiotherapy. Tumor-Treating-Fields (TTFields) are an antimitotic modality applying low-intensity (1-3 V/cm), intermediate-frequency (100-300 kHz) ...

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