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FOXA1 Gene Expression for Defining Molecular Subtypes of Muscle-Invasive Bladder Cancer after Radical Cystectomy

Sikic, Danijel ; Eckstein, Markus ; Wirtz, Ralph M. ; Jarczyk, Jonas ; Worst, Thomas S. ; Porubsky, Stefan ; Keck, Bastian ; Kunath, Frank ; Weyerer, Veronika ; Breyer, Johannes ; Otto, Wolfgang ; Rinaldetti, Sebastien ; Bolenz, Christian ; Hartmann, Arndt ; Wullich, Bernd ; Erben, Philipp



Abstract

It remains unclear how to implement the recently revealed basal and luminal subtypes of muscle-invasive bladder cancer (MIBC) into daily clinical routine and whether molecular marker panels can be reduced. The mRNA expression of basal (KRT5) and luminal (FOXA1, GATA3, KRT20) markers was measured by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) and correlated to ...

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