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mTORC2 Signaling Is Necessary for Timely Liver Regeneration after Partial Hepatectomy

Xu, Meng ; Wang, Haichuan ; Wang, Jingxiao ; Burhan, Deviana ; Shang, Runze ; Wang, Pan ; Zhou, Yi ; Li, Rong ; Liang, Bingyong ; Evert, Katja ; Utpatel, Kirsten ; Xu, Zhong ; Song, Xinhua ; Che, Li ; Calvisi, Diego F. ; Wang, Bruce ; Chen, Xi ; Zeng, Yong ; Chen, Xin



Abstract

Liver regeneration is a fundamental biological process required for sustaining body homeostasis and restoring liver function after injury. Emerging evidence demonstrates that cytokines, growth factors, and multiple signaling pathways contribute to liver regeneration. Mammalian target of rapamycin complex 2 (mTORC2) regulates cell metabolism, proliferation and survival. The major substrates for ...

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