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Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study

Heitmann, Henrik ; Haller, Bernhard ; Tiemann, Laura ; Mühlau, Mark ; Berthele, Achim ; Tölle, Thomas R. ; Salmen, Anke ; Ambrosius, Björn ; Bayas, Antonios ; Asseyer, Susanna ; Hartung, Hans-Peter ; Heesen, Christoph ; Stangel, Martin ; Wildemann, Brigitte ; Haars, Sarah ; Groppa, Sergiu ; Luessi, Felix ; Kümpfel, Tania ; Nischwitz, Sandra ; Meuth, Sven G. ; Klotz, Luisa ; Linker, Ralf A. ; Zettl, Uwe K. ; Ziemann, Ulf ; Tumani, Hayrettin ; Tackenberg, Björn ; Zipp, Frauke ; Wiendl, Heinz ; Gold, Ralf ; Hemmer, Bernhard ; Ploner, Markus


Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, and causal relationships between pain and biopsychosocial factors in MS are largely unknown. Longitudinal studies might help to clarify the prevalence and determinants of pain in MS. To this end, we analyzed ...


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