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Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation

Maertens, Johan ; Logan, Aaron C. ; Jang, Junho ; Long, Gwynn ; Tang, Jih-Luh ; Hwang, William Y. K. ; Koh, Liang Piu ; Chemaly, Roy ; Gerbitz, Armin ; Winkler, Julia ; Yeh, Su-Peng ; Hiemenz, John ; Christoph, Sandra ; Lee, Dong-Gun ; Wang, Po-Nan ; Holler, Ernst ; Mielke, Stephan ; Akard, Luke ; Yeo, Adeline ; Ramachandra, Sangana ; Smith, Kristin ; Pertel, Peter ; Segal, Florencia



Abstract

Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients, and treatment options are limited by toxicities. CSJ148 is a combination of two anti-HCMV human monoclonal antibodies (UP538 and UP539) that bind to and inhibit the functions of viral HCMV glycoprotein B (gB) and the pentameric complex, consisting of glycoproteins gH, gL, UL128, UL130, and UL131. In this ...

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