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Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model

Muschter, Dominique ; Fleischhauer, Lutz ; Taheri, Shahed ; Schilling, Arndt F. ; Clausen-Schaumann, Hauke ; Grässel, Susanne



Abstract

Numerous studies identified a role for the sensory neuropeptides substance P (SP) and alpha calcitonin generelated peptide (alpha CGRP) in osteoarthritis (OA) pain behavior. Surprisingly, little attention has been paid on how their trophic effects on cartilage and bone cells might affect structural changes of bone and cartilage in OA pathology. Here, we sought to elucidate sensory neuropeptides ...

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