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A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation

Jobin, Katarzyna ; Stumpf, Natascha E. ; Schwab, Sebastian ; Eichler, Melanie ; Neubert, Patrick ; Rauh, Manfred ; Adamowski, Marek ; Babyak, Olena ; Hinze, Daniel ; Sivalingam, Sugirthan ; Weisheit, Christina ; Hochheiser, Katharina ; Schmidt, Susanne V. ; Meissner, Mirjam ; Garbi, Natalio ; Abdullah, Zeinab ; Wenzel, Ulrich ; Hölzel, Michael ; Jantsch, Jonathan ; Kurts, Christian



Abstract

The Western diet is rich in salt, which poses various health risks. A high-salt diet (HSD) can stimulate immunity through the nuclear factor of activated T cells 5 (Nfat5)-signaling pathway, especially in the skin, where sodium is stored. The kidney medulla also accumulates sodium to build an osmotic gradient for water conservation. Here, we studied the effect of an HSD on the immune defense ...

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