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Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

Duscha, Alexander ; Gisevius, Barbara ; Hirschberg, Sarah ; Yissachar, Nissan ; Stangl, Gabriele I. ; Eilers, Eva ; Bader, Verian ; Haase, Stefanie ; Kaisler, Johannes ; David, Christina ; Schneider, Ruth ; Troisi, Riccardo ; Zent, Daniel ; Hegelmaier, Tobias ; Dokalis, Nikolaos ; Gerstein, Sara ; Del Mare-Roumani, Sara ; Amidror, Sivan ; Staszewski, Ori ; Poschmann, Gereon ; Stühler, Kai ; Hirche, Frank ; Balogh, Andras ; Kempa, Stefan ; Träger, Pascal ; Zaiss, Mario M. ; Holm, Jacob Bak ; Massa, Megan G. ; Nielsen, Henrik Bjørn ; Faissner, Andreas ; Lukas, Carsten ; Gatermann, Sören G. ; Scholz, Markus ; Przuntek, Horst ; Prinz, Marco ; Forslund, Sofia K. ; Winklhofer, Konstanze F. ; Müller, Dominik N. ; Linker, Ralf A. ; Gold, Ralf ; Haghikia, Aiden



Abstract

Short-chain fatty acids are processed from indigestible dietary fibers by gut bacteria and have immunomodulatory properties. Here, we investigate propionic acid (PA) in multiple sclerosis (MS), an autoimmune and neurodegenerative disease. Serum and feces of subjects with MS exhibited significantly reduced PA amounts compared with controls, particularly after the first relapse. In a ...

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