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Hermans, Dalton ; Gautam, Sanjivan ; García-Cañaveras, Juan C. ; Gromer, Daniel ; Mitra, Suman ; Spolski, Rosanne ; Li, Peng ; Christensen, Stephen ; Nguyen, Rosa ; Lin, Jian-Xin ; Oh, Jangsuk ; Du, Ning ; Veenbergen, Sharon ; Fioravanti, Jessica ; Ebina-Shibuya, Risa ; Bleck, Christopher ; Neckers, Leonard M. ; Rabinowitz, Joshua D. ; Gattinoni, Luca ; Leonard, Warren J.

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+T cell stemness and antitumor immunity

Hermans, Dalton, Gautam, Sanjivan, García-Cañaveras, Juan C. , Gromer, Daniel, Mitra, Suman, Spolski, Rosanne, Li, Peng, Christensen, Stephen, Nguyen, Rosa, Lin, Jian-Xin, Oh, Jangsuk, Du, Ning, Veenbergen, Sharon, Fioravanti, Jessica , Ebina-Shibuya, Risa, Bleck, Christopher , Neckers, Leonard M., Rabinowitz, Joshua D., Gattinoni, Luca and Leonard, Warren J. (2020) Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+T cell stemness and antitumor immunity. Proceedings of the National Academy of Sciences 117 (11), pp. 6047-6055.

Date of publication of this fulltext: 11 Oct 2021 13:00
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Item typeArticle
Journal or Publication TitleProceedings of the National Academy of Sciences
Publisher:NATL ACAD SCIENCES
Place of Publication:WASHINGTON
Volume:117
Number of Issue or Book Chapter:11
Page Range:pp. 6047-6055
Date2020
InstitutionsLeibniz Institute for Immunotherapy (LIT)
Identification Number
ValueType
10.1073/pnas.1920413117DOI
KeywordsMETABOLIC DEPENDENCY; MEMORY; DIFFERENTIATION; IMMUNOMETABOLISM; GLYCOLYSIS; IL-2; IL-21; LDH; adoptive immunotherapy; immunometabolism
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgYes
Item ID50192

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