Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+T cell stemness and antitumor immunity
Hermans, Dalton, Gautam, Sanjivan, García-Cañaveras, Juan C.
, Gromer, Daniel, Mitra, Suman, Spolski, Rosanne, Li, Peng, Christensen, Stephen, Nguyen, Rosa, Lin, Jian-Xin, Oh, Jangsuk, Du, Ning, Veenbergen, Sharon, Fioravanti, Jessica
, Ebina-Shibuya, Risa, Bleck, Christopher
, Neckers, Leonard M., Rabinowitz, Joshua D., Gattinoni, Luca
and Leonard, Warren J.
(2020)
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+T cell stemness and antitumor immunity.
Proceedings of the National Academy of Sciences 117 (11), pp. 6047-6055.
Date of publication of this fulltext: 11 Oct 2021 13:00
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| Item type | Article | ||||
| Journal or Publication Title | Proceedings of the National Academy of Sciences | ||||
| Publisher: | NATL ACAD SCIENCES | ||||
|---|---|---|---|---|---|
| Place of Publication: | WASHINGTON | ||||
| Volume: | 117 | ||||
| Number of Issue or Book Chapter: | 11 | ||||
| Page Range: | pp. 6047-6055 | ||||
| Date | 2020 | ||||
| Institutions | Leibniz Institute for Immunotherapy (LIT) | ||||
| Identification Number |
| ||||
| Keywords | METABOLIC DEPENDENCY; MEMORY; DIFFERENTIATION; IMMUNOMETABOLISM; GLYCOLYSIS; IL-2; IL-21; LDH; adoptive immunotherapy; immunometabolism | ||||
| Dewey Decimal Classification | 600 Technology > 610 Medical sciences Medicine | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| Item ID | 50192 |
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