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The role of HLA matching in unrelated donor hematopoietic stem cell transplantation for sickle cell disease in Europe

Gluckman, Eliane ; Fuente, Josu de la ; Cappelli, Barbara ; Scigliuolo, Graziana M. ; Volt, Fernanda ; Tozatto-Maio, Karina ; Rocha, Vanderson ; Tommaso, Mina ; O’Boyle, Farah ; Smiers, Frans ; Cunha-Riehm, Claudia Bettoni Da ; Calore, Elisabetta ; Bonanomi, Sonia ; Graphakos, Stelios ; Paisiou, Anna ; Albert, Michael H. ; Ruggeri, Annalisa ; Zecca, Marco ; Lankester, Arjan C. ; Corbacioglu, Selim



Abstract

We report the results of an analysis of unrelated allogeneic hematopoietic stem cell transplantations (HSCT) in 71 patients with sickle cell disease (SCD) transplanted in EBMT centers between 2005 and 2017. Median age was 9.3 years; graft type was bone marrow in 79% and peripheral blood in 21%. Recipient-donor HLA match at high resolution typing was 10/10 in 31, 9/10 in 20, and 8/10 in 4 ...

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