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LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice

Wang, Xin ; Li, Zhi-Tong ; Yan, Yue ; Lin, Penghui ; Tang, Wei ; Hasler, Daniele ; Meduri, Rajyalakshmi ; Li, Ye ; Hua, Min-Min ; Qi, Hui-Tao ; Lin, Di-Hang ; Shi, Hui-Juan ; Hui, Jingyi ; Li, Jinsong ; Li, Dangsheng ; Yang, Jian-Hua ; Lin, Jinzhong ; Meister, Gunter ; Fischer, Utz ; Liu, Mo-Fang



Zusammenfassung

U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing spliceosome, is heavily modified post-transcriptionally, with 2'-O-methylation being most common. The role of these modifications in pre-mRNA splicing as well as their physiological function in mammals have remained largely unclear. Here we report that the La-related protein LARP7 functions as a critical cofactor ...

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