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Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells

Nemade, Harshal ; Acharya, Aviseka ; Chaudhari, Umesh ; Nembo, Erastus ; Nguemo, Filomain ; Riet, Nicole ; Abken, Hinrich ; Hescheler, Jürgen ; Papadopoulos, Symeon ; Sachinidis, Agapios



Abstract

Application of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is limited by the challenges in their efficient differentiation. Recently, the Wingless (Wnt) signaling pathway has emerged as the key regulator of cardiomyogenesis. In this study, we evaluated the effects of cyclooxygenase inhibitors on cardiac differentiation of hPSCs. Cardiac differentiation was performed by adherent ...

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