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Efficient treatment of murine acute GvHD by in vitro expanded donor regulatory T cells

Riegel, Christin ; Boeld, Tina J. ; Doser, Kristina ; Huber, Elisabeth ; Hoffmann, Petra ; Edinger, Matthias


Acute graft-versus-host disease (aGvHD) is a frequent complication after allogeneic bone marrow/stem cell transplantation (BMT/SCT) induced by co-transplanted alloreactive conventional donor T cells. We previously demonstrated that the adoptive transfer of donor CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) at the time of BMT prevents aGvHD in murine models. Yet, the therapeutic potential of ...


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