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The zinc finger domains in U2AF26 and U2AF35 have diverse functionalities including a role in controlling translation

Herdt, Olga ; Reich, Stefan ; Medenbach, Jan ; Timmermann, Bernd ; Olofsson, Didrik ; Preußner, Marco ; Heyd, Florian



Abstract

Recent work has associated point mutations in both zinc fingers (ZnF) of the spliceosome component U2AF35 with malignant transformation. However, surprisingly little is known about the functionality of the U2AF35 ZnF domains in general. Here we have analysed key functionalities of the ZnF domains of mammalian U2AF35 and its paralog U2AF26. Both ZnFs are required for splicing regulation, whereas ...

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