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Enhanced CaMKII-Dependent Late I Na Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing

Lebek, Simon ; Pichler, Konstantin ; Reuthner, Kathrin ; Trum, Maximillian ; Tafelmeier, Maria ; Mustroph, Julian ; Camboni, Daniele ; Rupprecht, Leopold ; Schmid, Christof ; Maier, Lars S. ; Arzt, Michael ; Wagner, Stefan


Rationale: Sleep-disordered breathing (SDB) is frequently associated with atrial arrhythmias. Increased CaMKII (Ca/calmodulin-dependent protein kinase II) activity has been previously implicated in atrial arrhythmogenesis. Objective:We hypothesized that CaMKII-dependent dysregulation of Na current (I-Na) may contribute to atrial proarrhythmic activity in patients with SDB. Methods and Results: We ...


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