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Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF

Delacher, Michael ; Imbusch, Charles D. ; Hotz-Wagenblatt, Agnes ; Mallm, Jan-Philipp ; Bauer, Katharina ; Simon, Malte ; Riegel, Dania ; Rendeiro, André F. ; Bittner, Sebastian ; Sanderink, Lieke ; Pant, Asmita ; Schmidleithner, Lisa ; Braband, Kathrin L. ; Echtenachter, Bernd ; Fischer, Alexander ; Giunchiglia, Valentina ; Hoffmann, Petra ; Edinger, Matthias ; Bock, Christoph ; Rehli, Michael ; Brors, Benedikt ; Schmidl, Christian ; Feuerer, Markus



Abstract

Specialized regulatory T (Treg) cells accumulate and perform homeostatic and regenerative functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg cells exist and how they differentiate remain elusive. Using transcription factor nuclear factor, interleukin 3 regulated (Nfil3) reporter mice and single-cell RNA-sequencing (scRNA-seq), we identified two precursor ...

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