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Gait variability as digital biomarker of disease severity in Huntington’s disease

Gaßner, Heiko ; Jensen, Dennis ; Marxreiter, F. ; Kletsch, Anja ; Bohlen, Stefan ; Schubert, Robin ; Muratori, Lisa M. ; Eskofier, Bjoern ; Klucken, Jochen ; Winkler, Jürgen ; Reilmann, Ralf ; Kohl, Zacharias


Background Impaired gait plays an important role for quality of life in patients with Huntington's disease (HD). Measuring objective gait parameters in HD might provide an unbiased assessment of motor deficits in order to determine potential beneficial effects of future treatments. Objective To objectively identify characteristic features of gait in HD patients using sensor-based gait analysis. ...


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