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Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis

Mancarella, Serena ; Serino, Grazia ; Dituri, Francesco ; Cigliano, Antonio ; Ribback, Silvia ; Wang, Jingxiao ; Chen, Xin ; Calvisi, Diego F. ; Giannelli, Gianluigi



Abstract

Intrahepatic cholangiocarcinoma (iCCA) is a deadly disease with rising incidence and few treatment options. An altered expression and/or activation of NOTCH1-3 receptors has been shown to play a role in iCCA development and progression. In this study, we established a new CCA patient-derived xenograft model, which was validated by immunohistochemistry and transcriptomic analysis. The effects of ...

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