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Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver

Buniatian, Gayane Hrachia ; Weiskirchen, Ralf ; Weiss, Thomas S. ; Schwinghammer, Ute ; Fritz, Martin ; Seferyan, Torgom ; Proksch, Barbara ; Glaser, Michael ; Lourhmati, Ali ; Buadze, Marine ; Borkham-Kamphorst, Erawan ; Gaunitz, Frank ; Gleiter, Christoph H. ; Lang, Thomas ; Schaeffeler, Elke ; Tremmel, Roman ; Cynis, Holger ; Frey, William H. ; Gebhardt, Rolf ; Friedman, Scott L. ; Mikulits, Wolfgang ; Schwab, Matthias ; Danielyan, Lusine


The function and regulation of amyloid-beta (A beta) in healthy and diseased liver remains unexplored. Because A beta reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal and cirrhotic liver. A beta and key proteins that generate (beta-secretase 1 and presenilin-1) and degrade it (neprilysin and myelin basic ...


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