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Simulated Microgravity Influences VEGF, MAPK, and PAM Signaling in Prostate Cancer Cells

Hybel, Trine Engelbrecht ; Dietrichs, Dorothea ; Sahana, Jayashree ; Corydon, Thomas J. ; Nassef, Mohamed Z. ; Wehland, Markus ; Krüger, Marcus ; Magnusson, Nils E. ; Bauer, Johann ; Utpatel, Kirsten ; Infanger, Manfred ; Grimm, Daniela ; Kopp, Sascha


Prostate cancer is one of the leading causes of cancer mortality in men worldwide. An unusual but unique environment for studying tumor cell processes is provided by microgravity, either in space or simulated by ground-based devices like a random positioning machine (RPM). In this study, prostate adenocarcinoma-derived PC-3 cells were cultivated on an RPM for time periods of 3 and 5 days. We ...


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