Zimmermann, Katharina ; Kuehle, Johannes ; Dragon, Anna Christina 
; Galla, Melanie ; Kloth, Christina ; Rudek, Loreen Sophie ; Sandalcioglu, I. Erol ; Neyazi, Belal ; Moritz, Thomas ; Meyer, Johann ; Rossig, Claudia ; Altvater, Bianca ; Eiz-Vesper, Britta ; Morgan, Michael Alexander ; Abken, Hinrich ; Schambach, Axel
; Galla, Melanie ; Kloth, Christina ; Rudek, Loreen Sophie ; Sandalcioglu, I. Erol ; Neyazi, Belal ; Moritz, Thomas ; Meyer, Johann ; Rossig, Claudia ; Altvater, Bianca ; Eiz-Vesper, Britta ; Morgan, Michael Alexander ; Abken, Hinrich ; Schambach, Axel 
Abstract
Genetically modified T cells expressing chimeric antigen receptors (CARs) so far have mostly failed in the treatment of solid tumors owing to a number of limitations, including an immunosuppressive tumor microenvironment and insufficient CAR T cell activation and persistence. Next-generation approaches using CAR T cells that secrete transgenic immunomodulatory cytokines upon CAR signaling, known ...
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