| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie | ||||
| Publisher: | GEORG THIEME VERLAG KG | ||||
| Place of Publication: | STUTTGART | ||||
| Volume: | 145 | ||||
| Number of Issue or Book Chapter: | 01 | ||||
| Page Range: | pp. 89-98 | ||||
| Date: | 2020 | ||||
| Institutions: | Medicine > Abteilung für Thoraxchirurgie | ||||
| Identification Number: |
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| Keywords: | MALIGNANT PLEURAL MESOTHELIOMA; CYTOREDUCTIVE SURGERY; PHASE-II; EXTRAPLEURAL PNEUMONECTOMY; INTRAPLEURAL CHEMOTHERAPY; CISPLATIN; PERFUSION; PLEURECTOMY; PLEURECTOMY/DECORTICATION; RECURRENCE; regional chemotherapy; locoregional therapy; hyperthermic intrathoracic chemotherapy; HITOC | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 50356 |
Web of ScienceAbstract
Introduction During the last few years, hyperthermic intrathoracic chemotherapy (HITOC) has been performed in several departments for thoracic surgery in Germany. The objective of this expert recommendation is to provide elementary recommendations for a standardised HITOC treatment, which are based on clinical experiences and research data. Methods Between October and December 2018, a group of ...
Abstract
Introduction During the last few years, hyperthermic intrathoracic chemotherapy (HITOC) has been performed in several departments for thoracic surgery in Germany. The objective of this expert recommendation is to provide elementary recommendations for a standardised HITOC treatment, which are based on clinical experiences and research data. Methods Between October and December 2018, a group of experts for thoracic surgery in five departments of thoracic surgery developed recommendations for the HITOC procedure in Germany. These experts were selected by the latest national survey for HITOC and had the most clinical experience with HITOC. All recommendations are based on clinical experience, the experts' research data and recent literature. Results All recommendations were evaluated by all participating departments in one consensus survey. Finally, a total of six main conclusions including a total of 17 recommenda-tions were developed. For each recommendation, the strength of the consensus is presented in percentages. 100% agreement was established for nomenclature, technique, the chemotherapeutic agent, the perioperative management, the safety measures and the indications for HITOC. All experts recommended cisplatin as the first choice chemotherapeutic agent for HITOC. The dosage of cisplatin is specified in mg/m(2) body surface area (BSA) and should be between 150 and 175 mg/m(2) BSA. The volume of the perfusion fluid (approximately 4-5 l) seems to play a role for the concentration gradient of cisplatin and should therefore also be taken into account. Conclusions These expert recommendations provide a standardised and consistent implementation of the HITOC procedure. On this basis, postoperative complications associated to HITOC should be reduced and comparison of the results should be improved.
Metadata last modified: 11 Oct 2021 13:02
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