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Generation and characterization of a mitotane-resistant adrenocortical cell line

Seidel, Eric ; Walenda, Gudrun ; Messerschmidt, Clemens ; Obermayer, Benedikt ; Peitzsch, Mirko ; Wallace, Paal ; Bahethi, Rohini ; Yoo, Taekyeong ; Choi, Murim ; Schrade, Petra ; Bachmann, Sebastian ; Liebisch, Gerhard ; Eisenhofer, Graeme ; Beule, Dieter ; Scholl, Ute I


Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy. To investigate the underlying mechanisms in vitro, we here generated mitotane-resistant cell lines. After long-term pulsed treatment of HAC-15 human adrenocortical carcinoma cells with 70 mu M mitotane, we isolated monoclonal cell ...


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