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Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA

Strobl, Carolin Dorothea ; Schaffer, Stefanie ; Haug, Tabea ; Völkl, Simon ; Peter, Katrin ; Singer, Katrin ; Böttcher, Martin ; Mougiakakos, Dimitrios ; Mackensen, Andreas ; Aigner, Michael



Zusammenfassung

Genetic alterations in tumor cells provide promising targets for antitumor therapy. Recently, loss of methylthioadenosine phosphorylase (MTAP), a deletion frequently occurring in cancer, has been shown to create vulnerability to the inhibition of the protein arginine methyltransferase 5 (PRMT5). MTAP deficiency leads to accumulation of methylthioadenosine (MTA), which reduces PRMT5 activity, and ...

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