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Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

Rendeiro, André F. ; Krausgruber, Thomas ; Fortelny, Nikolaus ; Zhao, Fangwen ; Penz, Thomas ; Farlik, Matthias ; Schuster, Linda C. ; Nemc, Amelie ; Tasnády, Szabolcs ; Réti, Marienn ; Mátrai, Zoltán ; Alpár, Donát ; Bödör, Csaba ; Schmidl, Christian ; Bock, Christoph



Abstract

The Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for patients with chronic lymphocytic leukemia (CLL), despite extensive heterogeneity in this disease. To define the underlining regulatory dynamics, we analyze high-resolution time courses of ibrutinib treatment in patients with CLL, combining immune-phenotyping, single-cell transcriptome profiling, and chromatin ...

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