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Structure-function relationships of HDL in diabetes and coronary heart disease

Cardner, Mathias ; Yalcinkaya, Mustafa ; Goetze, Sandra ; Luca, Edlira ; Balaz, Miroslav ; Hunjadi, Monika ; Hartung, Johannes ; Shemet, Andrej ; Kränkel, Nicolle ; Radosavljevic, Silvija ; Keel, Michaela ; Othman, Alaa ; Karsai, Gergely ; Hornemann, Thorsten ; Claassen, Manfred ; Liebisch, Gerhard ; Carreira, Erick ; Ritsch, Andreas ; Landmesser, Ulf ; Krützfeldt, Jan ; Wolfrum, Christian ; Wollscheid, Bernd ; Beerenwinkel, Niko ; Rohrer, Lucia ; von Eckardstein, Arnold



Abstract

High-density lipoproteins (HDL) contain hundreds of lipid species and proteins and exert many potentially vasoprotective and antidiabetogenic activities on cells. To resolve structure-function-disease relationships of HU, we characterized HDL of 51 healthy subjects and 98 patients with diabetes (T2DM), coronary heart disease (CHD), or both for protein and lipid composition, as well as ...

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