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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Aegerter, Helena ; Kulikauskaite, Justina ; Crotta, Stefania ; Patel, Harshil ; Kelly, Gavin ; Hessel, Edith M. ; Mack, Matthias ; Beinke, Soren ; Wack, Andreas


Respiratory infections occur throughout life but how this shapes the lung immune system through time is unclear. Wack and colleagues show that a previous influenza infection recruits monocytes to the lung, which then assume an alveolar macrophage-like phenotype and mediate long-term antibacterial protection. Despite the prevalence and clinical importance of influenza, its long-term effect on lung ...


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