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In vivo detection of breast cancer liver metastases in humanized tumour mice using tumour specific contrast agent BR55®

Bitterer, Florian ; Hornung, Matthias ; Platz Batista da Silva, Natascha ; Schlitt, Hans J. ; Stroszczynski, Christian ; Wege, Anja K. ; Jung, Ernst-Michael


OBJECTIVE: To investigate the diagnostic accuracy of high-resolution ultrasound (HRU) for the detection of hepatic metastases of breast cancer in a humanized tumour mouse (HTM) using clinical standard technology. In addition, the efficiency of standard contrast-enhanced ultrasound (CEUS) [microbubbles of sulphur hexafluoride] and CEUS using a novel VEGFR2-targeted contrast agent [BR55 (R)] was ...


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