| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Clinical Hemorheology and Microcirculation | ||||
| Publisher: | IOS PRESS | ||||
| Place of Publication: | AMSTERDAM | ||||
| Volume: | 74 | ||||
| Number of Issue or Book Chapter: | 3 | ||||
| Page Range: | pp. 327-339 | ||||
| Date: | 2020 | ||||
| Institutions: | Medicine > Lehrstuhl für Röntgendiagnostik | ||||
| Identification Number: |
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| Keywords: | CLINICAL-PRACTICE RECOMMENDATIONS; HEPATOCELLULAR-CARCINOMA; NODULAR HYPERPLASIA; PROSPECTIVE MULTICENTER; DIAGNOSTIC PERFORMANCE; DIFFERENTIAL-DIAGNOSIS; PRACTICE GUIDELINES; MANAGEMENT; CIRRHOSIS; PATTERN; CEUS; focal liver lesions; sonography; contrast-enhanced ultrasound; liver ultrasound | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 50443 |
Web of ScienceAbstract
BACKGROUND: Contrast-enhanced ultrasound (CEUS) has been used as an additional imaging technique in order to evaluate focal liver lesions. CEUS is easy and fast to perform, overcomes the limitations of B-mode US. OBJECTIVE: To evaluate the diagnostic potential of contrast-enhanced ultrasound (CEUS) in focal liver lesions (FLL) with unclear findings on computed tomography (CT) or magnetic ...
Abstract
BACKGROUND: Contrast-enhanced ultrasound (CEUS) has been used as an additional imaging technique in order to evaluate focal liver lesions. CEUS is easy and fast to perform, overcomes the limitations of B-mode US. OBJECTIVE: To evaluate the diagnostic potential of contrast-enhanced ultrasound (CEUS) in focal liver lesions (FLL) with unclear findings on computed tomography (CT) or magnetic resonance imaging (MRI). METHODS: In this single-center retrospective study, 146 patients with at least one FLL underwent additional CEUS of the liver to clarify inconclusive cross-sectional imaging findings. Ultrasonography was performed using B-mode imaging and CEUS after injection of sulphur hexafluoride microbubbles (second-generation contrast agent) within two months after ceMRI or ceCT and interpreted by an experienced radiologist (EFSUMB level 3). Histopathological reports, long-term follow-up or clinical course served as reference standard. RESULTS: Thirty-eight of the 146 patients had malignant and 108 benign FLL. Overall, CEUS had 92% sensitivity (95%-CI, 79-97) and 98% specificity (95%-CI, 93-99) with an AUC of 0.95 in correctly characterizing the lesion as malignant or benign. Sensitivity increased to 98% (95%-CI, 96-100) for benign lesions and decreased to 92% (95%-CI, 78-98) for malignant lesions. CEUS showed the highest diagnostical accuracy in lesion <1 cm with an AUC of 1.000, while the lowest accuracy was achieved in lesions >2 cm with an AUC of 0.924 due to a decreasing specificity of 86% (95%-CI, 87-100). CONCLUSION: CEUS correctly distinguished malignant from benign FLL in cases with inconclusive cross-sectional imaging findings and achieved high levels of diagnostic accuracy. CEUS has added diagnostic value especially in small lesions <= 1 cm while specificity remains limited in larger lesions.
Metadata last modified: 11 Oct 2021 13:05
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