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Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension

Richter, Manuel J. ; Harutyunova, Satenik ; Bollmann, Tom ; Classen, Simon ; Fuge, Jan ; Gall, Henning ; Gerhardt, Felix ; Ghofrani, Hossein A. ; Gunkel, Hartmut ; Grünig, Ekkehard ; Halank, Michael ; Heine, Alexander ; Klose, Hans ; Lange, Tobias J. ; Neurohr, Claus ; Nickolaus, Kai ; Opitz, Christian F. ; Rosenkranz, Stephan ; Seyfarth, Hans-Jürgen ; Tello, Khodr ; Ewert, Ralf ; Olsson, Karen M.


Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro (R) pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory.

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