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Characterization of glycolysis-related gene expression in malignant melanoma

Koch, Andreas ; Ebert, Eva Vanessa ; Seitz, Tatjana ; Dietrich, Peter ; Berneburg, Mark ; Bosserhoff, Anja ; Hellerbrand, Claus


Malignant melanoma exhibits a distinct metabolic phenotype with high glycolytic activity. Previously, we have shown that glucose transporter isoform 1 (GLUT1) favors growth and metastasis of malignant melanoma. In this study, we investigated the expression of GLUT1 and the further glycolysis-related genes hexokinase 1 and 2 (HK1, HK2), lactate dehydrogenase A (LDH-A) and monocarboxylate ...


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