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Ca2+/calmodulin-dependent protein kinase II is essential in hyperacute pressure overload

Baier, Maria J. ; Klatt, Susanne ; Hammer, Karin P. ; Maier, Lars S. ; Rokita, Adam G.



Abstract

Background: Activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) is established as a central intracellular trigger for various cardiac pathologies such as hypertrophy, heart failure or arrhythmias in animals and humans suggesting CaMKII as a promising target protein for future medical treatments. However, the physiological role of CaMKII is scarcely well defined. Aim & methods: To ...

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