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New antifungal ent-labdane diterpenes against Candida glabrata produced by microbial transformation of ent-polyalthic acid

Pontes de Sousa, Ingrid ; Ferreira, Antônio Gilberto ; Miller Crotti, Antônio Eduardo ; Alves dos Santos, Raquel ; Kiermaier, Josef ; Kraus, Birgit ; Heilmann, Jörg ; Jacometti Cardoso Furtado, Niege Araçari


Candida glabrata, the most common non-albicans Candida species and one of the primary causes of candidemia, exhibits decreased susceptibility to azoles and more recently to echinocandins. Polyalthic acid 1, a furan diterpene, has been shown promising biological potential and in this study ent-polyalthic acid derivatives with antifungal activity against Candida glabrata were produced by microbial ...


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