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Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

Campos, Gisela ; Schmidt-Heck, Wolfgang ; De Smedt, Jonathan ; Widera, Agata ; Ghallab, Ahmed ; Pütter, Larissa ; González, Daniela ; Edlund, Karolina ; Cadenas, Cristina ; Marchan, Rosemarie ; Guthke, Reinhard ; Verfaillie, Catherine ; Hetz, Claudio ; Sachinidis, Agapios ; Braeuning, Albert ; Schwarz, Michael ; Weiß, Thomas S. ; Banhart, Benjamin K. ; Hoek, Jan ; Vadigepalli, Rajanikanth ; Willy, Jeffrey ; Stevens, James L. ; Hay, David C. ; Hengstler, Jan G. ; Godoy, Patricio


Inflammation has been recognized as essential for restorative regeneration. Here, we analyzed the sequential processes during onset of liver injury and subsequent regeneration based on time-resolved transcriptional regulatory networks (TRNs) to understand the relationship between inflammation, mature organ function, and regeneration. Genome-wide expression and TRN analysis were performed time ...


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