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Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

Che, Li ; Chi, Wenna ; Qiao, Yu ; Zhang, Jie ; Song, Xinhua ; Liu, Ye ; Li, Lei ; Jia, Jiaoyuan ; Pilo, Maria G. ; Wang, Jingxiao ; Cigliano, Antonio ; Ma, Zhilong ; Kuang, Wenhua ; Tang, Zefang ; Zhang, Zemin ; Shui, Guanghou ; Ribback, Silvia ; Dombrowski, Frank ; Evert, Matthias ; Pascale, Rosa Maria ; Cossu, Carla ; Pes, Giovanni Mario ; Osborne, Timothy F. ; Calvisi, Diego F. ; Chen, Xin ; Chen, Ligong



Abstract

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Design We investigated the functional contribution of fatty acid synthase (Fasn)-mediated de novo FA synthesis in a murine HCC model induced by loss of Pten and overexpression of c-Met (sgPten/c-Met) using ...

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