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Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora

Macabeo, Allan Patrick G. ; Flores, Angeli Izza G. ; Fernandez, Rey Arturo T. ; Budde, Simon ; Faderl, Christian ; Dahse, Hans-Martin ; Franzblau, Scott G.



Abstract

Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds. Among the compounds isolated, zeylenone (3) showed moderate antitubercular activity against Mycobacterium tuberculosis H(37)Rv with MIC90 value of 51.2 mu M and antiproliferative ...

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