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Anhedonia induced by high-fat diet in mice depends on gut microbiota and leptin

Hassan, Ahmed M. ; Mancano, Giulia ; Kashofer, Karl ; Liebisch, Gerhard ; Farzi, Aitak ; Zenz, Geraldine ; Claus, Sandrine P. ; Holzer, Peter


Objectives:Imbalanced nutrition and obesity are risk factors for depression, a relationship that in rodents can be modeled by depression-like behavior in response to high-fat diet (HFD). In this work, we examined the role of the intestinal microbiota and the adipocytokine leptin as potential mediators of the effects of HFD to induce anhedonia-like behavior and reduce self-care in mice. ...


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