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Natriuretic peptides relax human intrarenal arteries through natriuretic peptide receptor type‐A recapitulated by soluble guanylyl cyclase agonists

Frees, Andreas ; Assersen, Kasper B. ; Jensen, Mia ; Hansen, Pernille B.L. ; Vanhoutte, Paul M. ; Madsen, Kirsten ; Federlein, Anna ; Lund, Lars ; Toft, Anja ; Jensen, Boye L.



Abstract

Aim Natriuretic peptides, BNP and ANP increase renal blood flow in experimental animals. The signalling pathway in human kidney vasculature is unknown. It was hypothesized that BNP and ANP cause endothelium-independent relaxation of human intrarenal arteries by vascular natriuretic peptide receptor-A, but not -B and -C, which is mimicked by agonists of soluble guanylyl cyclase sGC. Methods Human ...

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