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Mechanisms controlling bacterial infection in myeloid cells under hypoxic conditions

Hayek, Inaya ; Schatz, Valentin ; Bogdan, Christian ; Jantsch, Jonathan ; Lührmann, Anja




Abstract

Various factors of the tissue microenvironment such as the oxygen concentration influence the host-pathogen interaction. During the past decade, hypoxia-driven signaling via hypoxia-inducible factors (HIF) has emerged as an important factor that affects both the pathogen and the host. In this chapter, we will review the current knowledge of this complex interplay, with a particular emphasis given ...

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