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Nuclear ErbB2 expression in hepatocytes in liver disease

Döring, Paula ; Calvisi, Diego F. ; Dombrowski, Frank




Abstract

ErbB2 is a prominent representative of the epidermal growth factor receptors that mainly attract attention as oncogenic drivers and therapeutic targets in cancer. Besides transmembrane signaling, ErbB2 may also translocate into the nucleus and mediate distinct nuclear signaling effects including DNA repair and cell cycle arrest. Unexpectedly, we found nuclear ErbB2 expression in human hepatocytes ...

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