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Characterisation of human tissue-resident T-regulatory cells in healthy tissues and in-vitro generation of tissue-like Treg cells with wound-healing capabilities

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Sanderink, Lieke Marie Antoinet
Date of publication of this fulltext: 24 Nov 2021 10:12

Abstract (English)

Regulatory T cells (Tregs) are characterized by the expression of FOXP3 and are important for regulating other cellular components of the immune system. Their absence leads to autoimmune diseases like the “Scurfy phenotype” in mice or the Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome in humans. Non-lymphoid tissue (NLT) Tregs are distinct from lymphoid tissue (LT) ...


Translation of the abstract (German)

Regulatorische T-Zellen (Tregs) zeichnen sich durch die Expression von FOXP3 aus und sind wichtig für die Regulierung anderer zellulärer Komponenten des Immunsystems. Ihr Fehlen führt zu Autoimmunerkrankungen wie dem "Scurfy-Phänotyp" bei Mäusen oder dem Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) Syndrom beim Menschen. Tregs aus nicht-lymphoidem Gewebe (NLT) ...


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