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Cardiac Effects of Novel Histamine H2 Receptor Agonists

Gergs, Ulrich ; Büxel, Maren L. ; Bresinsky, Merlin ; Kirchhefer, Uwe ; Fehse, Charlotte ; Höring, Carina ; Hofmann, Britt ; Marušáková, Margaréta ; Čináková, Aneta ; Schwarz, Rebecca ; Pockes, Steffen ; Neumann, Joachim


In an integrative approach, we studied cardiac effects of recently published novel H2 receptor agonists in the heart of mice that overexpress the human H2 receptor (H2-TG mice) and littermate wild type (WT) control mice and in isolated electrically driven muscle preparations from patients undergoing cardiac surgery. Under our experimental conditions, the H2 receptor agonists UR-Po563, UR-MB-158, ...


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