Abstract
BACKGROUND :
Autologous peripheral blood progenitor cells (PBPCs) are usually collected after the administration of conventional-dose chemotherapy (CDCT) and growth factors. However, there are no data available concerning the collection of PBPCs after high-dose chemotherapy (HDCT) and autologous hematopoietic transplantation in a larger series.
STUDY DESIGN AND METHODS :
Patients (n = 30) ...
Abstract
BACKGROUND :
Autologous peripheral blood progenitor cells (PBPCs) are usually collected after the administration of conventional-dose chemotherapy (CDCT) and growth factors. However, there are no data available concerning the collection of PBPCs after high-dose chemotherapy (HDCT) and autologous hematopoietic transplantation in a larger series.
STUDY DESIGN AND METHODS :
Patients (n = 30) underwent leukapheresis for PBPC harvest after CDCT. After HDCT and autografting, the collection of a second PBPC autograft was attempted.
RESULTS :
Leukapheresis was performed after CDCT in all cases at a median of 118 CD34+ cells per μL (range, 18-589) and resulted in 6.4 × 10 6 CD34+ cells per kg (range, 1.7-29.0). After HDCT and autografting, 24 patients (80%) underwent secondary leukapheresis, although they had a significantly lower median of peripheral blood (PB) CD34+ cells (30/μL; range, 10-171; p < 0.001). In these patients a median of 3.6 × 10 6 CD34+ cells per kg (range, 1.6-10.1) was collected in the post-transplantation course. In the remaining six patients (20%) with PB CD34+ cells < 10 per μL, no PBPC harvesting was performed. These so-called poor mobilizers had received significantly less CD34+ cells for autologous transplantation than patients with successful post-HDCT mobilization (median, 2.5 × 10 6 /kg [range, 1.7-3.0] vs. 6.5 × 10 6 /kg [range, 3.2-19.6]; p < 0.001).
CONCLUSION :
Collection of PBPCs is possible in most patients during the recovery phase of hematopoiesis after HDCT plus autografting, and the number of circulating PBPCs may be related to the CD34+ cell dose transfused by the preceding autograft.
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