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Stored platelets alter glycerophospholipid and sphingolipid species, which are differentially transferred to newly released extracellular vesicles

Pienimaeki-Roemer, Annika ; Ruebsaamen, Katharina ; Boettcher, Alfred ; Orsó, Evelyn ; Scherer, Max ; Liebisch, Gerhard ; Kilalic, Dzenan ; Ahrens, Norbert ; Schmitz, Gerd


BACKGROUND: Stored platelet concentrates (PLCs) for transfusion develop a platelet storage lesion (PSL), resulting in decreased platelet (PLT) viability and function. The processes leading to PSL have not been described in detail and no data describe molecular changes occurring in all three components of stored PLCs: PLTs, PLC extracellular vesicles (PLC-EVs), and plasma. STUDY DESIGN AND ...


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