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HIF-1BETA determines ABCA1 expression under hypoxia in human macrophages-A potential target for cardiovascular protection

Ugocsai, U. P. ; Ahrens, Norbert ; Schmitz, Gerd


Background: ATP-binding cassette transporter A1 (ABCA1) is a plasmamembrane protein that is primarily involved in high-density lipoprotein(HDL) production in liver cells and in the elimination of intracellularcholesterol in peripheral tissues. Functional deficiency of this protein leadsto low levels of circulating HDL, a clinical condition called Tangier’s disease. In peripheral tissues impaired ...


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