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mdm2 gene amplification is associated with luminal breast cancer progression in humanized PDX mice and a worse outcome of estrogen receptor positive disease

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Wege, Anja Kathrin ; Rom‐Jurek, Eva‐Maria ; Jank, Paul ; Denkert, Carsten ; Ugocsai, Peter ; Solbach, Christine ; Blohmer, Jens‐Uwe ; Sinn, Bruno ; Mackelenbergh, Marion ; Möbus, Volker ; Trumpp, Andreas ; Marangoni, Elisabetta ; Pfarr, Nicole ; Irlbeck, Christoph ; Warfsmann, Jens ; Polzer, Bernhard ; Weber, Florian ; Ortmann, Olaf ; Loibl, Sibylle ; Vladimirova, Valentina ; Brockhoff, Gero
License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 11 Jan 2022 07:17

This publication is part of the DEAL contract with Wiley.


Estrogen receptor-positive breast cancer is a highly prevalent but heterogeneous disease among women. Advanced molecular stratification is required to enable individually most efficient treatments based on relevant prognostic and predictive biomarkers. First objective of our study was the hypothesis-driven discovery of biomarkers involved in tumor progression upon xenotransplantation of Luminal ...


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