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Soluble CD137 is a novel serum marker of liver cirrhosis in patients with hepatitis C and alcohol‐associated disease etiology

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Weigand, Kilian ; Peschel, Georg ; Grimm, Jonathan ; Luu, Khang ; Schacherer, Doris ; Wiest, Reiner ; Müller-Schilling, Martina ; Schwarz, Herbert ; Buechler, Christa
License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 11 Jan 2022 07:29

This publication is part of the DEAL contract with Wiley.


Defective T-cell functions play a role in the persistence of HCV infection. Activated T cells express CD137, which costimulates antivirus T-cell responses, and this activity is antagonized by soluble CD137 (sCD137). Here, we show that in sera of 81 patients with chronic HCV, sCD137 levels did not correlate with measures of viral infection, and did not decline after virus eradication using ...


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