Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors

URN to cite this document:: urn:nbn:de:bvb:355-epub-513972
DOI to cite this document:: 10.5283/epub.51397

Seibel-Ehlert, Ulla

; Plank, Nicole ; Inoue, Asuka ; Bernhardt, Guenther

; Strasser, Andrea

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Date of publication of this fulltext: 12 Jan 2022 10:54

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Abstract

G protein activation represents an early key event in the complex GPCR signal transduction process and is usually studied by label-dependent methods targeting specific molecular events. However, the constrained environment of such "invasive" techniques could interfere with biological processes. Although histamine receptors (HRs) represent (evolving) drug targets, their signal transduction is not ...